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The interaction between β-K 4H 3 [SiW 9O 37(CpTi) 3]·11H 2O and DNA was investigated by agarose gel electrophoresis. The results suggest that β-K 4H 3[SiW 9O 37(CpTi) 3]·11H 2O can degrade the genomic DNA. The treatment of plasmid DNA with β-K 4H 3 [SiW 9O 37(CpTi) 3]·11H 2O resulted in a fast moving band in front of the three normal conformations(super coiled DNA, linear DNA and relaxed circular DNA) in agarose gel electrophoresis . These results indicate that this chemical material may have the ability to specifically cleavage DNA or to alter conformation of DNA molecules.
The interaction between β-K 4H 3 [SiW 9O 37 (CpTi) 3] · 11H 2O and DNA was investigated by agarose gel electrophoresis. The results suggest that β-K 4H 3 [SiW 9O 37 (CpTi) 3] · 11H 2O The treatment of plasmid DNA with β-K 4H 3 [SiW 9O 37 (CpTi) 3] · 11H 2O resulted in a fast moving band in front of the three normal conformations (super coiled DNA, linear DNA and relaxed circular DNA) in agarose gel electrophoresis. These results that that to specific cleavage DNA or to alter conformation of DNA molecules.