本文报告二巯基敌枯双所致大鼠甲状腺肿的形态发生。新形成的继发滤泡起源于原滤泡上皮。其发生过程经历了原滤泡上皮增生复层化,实心芽形成,实心滤泡细胞团形成,空心滤泡细胞团形成以及继发滤泡形成5个阶段。由滤泡上皮增生发展到甲状腺肿,经历了原发增生期、非成熟性改建期、继发增生期以及成熟性改建期4个时期。本文对甲状腺肿形成的机理作了简要讨论。 This article reports the occurrence of goitre in rats induced by dimercaprolactam. The newly formed secondary follicles originate from the original follicular epithelium. The occurrence process of the original follicular epithelial hyperplasia stratification, solid bud formation, solid follicular cell formation, hollow follicular cell mass formation and secondary follicular formation in five stages. By the follicular epithelial hyperplasia to goiter, undergoing primary proliferative phase, non-maturation of the reconstructive phase, secondary hyperplasia and maturation of the four periods. This article briefly discusses the mechanism of goiter formation.