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采用改进的ＰＣＲ法研究自发性高血压大鼠、肾性高血压大鼠与相应的对照大鼠（ＷＫＹ、Ｗｉｓｔａｒ），以及ＳＤ大鼠肾素基因第一内含子中可变串联重复序列（ＶＮＴＲ）．结果表明：正常ＷＫＹ、Ｗｉｓｔａｒ和ＳＤ大鼠，两个等位基因上的ＶＮＴＲ可呈现不同长度，形成杂合状态，其基因型有２．０ｋｂ／２．０ｋｂ、２．０ｋｂ／１．８ｋｂ、１．８ｋｂ／１．８ｋｂ３种。肾性高血压大鼠ＶＮＴＲ的基因型与正常无异；而自发性高血压大鼠两个等位基因上的ＶＮＴＲ均出现显著缺失，拷贝数比正常状态减少了５０％，其基因型为１．０ｋｂ／１．０ｋｂ。提示高血压的病因和发病机理是复杂的，遗传性高血压具有一定的分子基础。
In this study, spontaneous hypertensive rats, renal hypertensive rats and their corresponding control rats (WKY and Wistar), as well as the variable tandem repeats in the first intron of renin gene of SD rats VNTR). The results showed that in normal WKY, Wistar and SD rats, the VNTRs of the two alleles were heterozygous with different lengths and their genotypes were 2.0kb / 2.0kb, 2.0kb / 1.8kb, 1.8kb / 1.8kb3 species. The genotype of VNTR in renal hypertensive rats is no different from the normal one. However, the VNTRs of both alleles in spontaneously hypertensive rats are significantly deleted, the copy number is reduced by 50% compared with the normal state, and the genotype is 1 .0kb / 1.0kb. Tip etiology and pathogenesis of hypertension is complex, hereditary hypertension has some molecular basis.