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作者用双盲法对74例(152处感染)皮癣菌病患者作口服酮康唑(K)和灰黄霉素(G)疗效比较研究。K组37例病人80处感染,G组37例病人72处感染。两组年龄、性别、体重和身高均无明显差异。每日口服剂量K和G组分别为200mg和500mg,如3个月后无明显临床效果则用加倍剂量,达到临床和菌学上好转或给药达1年时即停止治疗。结果是:感染处的治愈率K和G组分别为75%和74%;指甲感染两
The authors compared the efficacy of ketoconazole (K) and griseofulvin (G) in 74 patients with dermatophytosis (152 infections) by double-blind method. Thirty-seven patients in group K were infected at 80, and 37 patients in group G were infected at 72. There were no significant differences in age, sex, weight and height between the two groups. Daily oral doses of K and G were 200mg and 500mg, respectively, if no obvious clinical effect after 3 months is doubled dose to achieve clinical and bacteriological improvement or administration of 1 year to stop treatment. The result was: The cure rate at infection was 75% and 74% in group K and G, respectively; nails infected two