目的观察胃镜下食管静脉曲张结扎术并小剂量硬化剂（联合组）治疗食管静脉曲张的疗效。方法６９例食管静脉曲张破裂出血病情稳定的病人随机分为三组，２５例接受胃镜下食管静脉曲张结扎术并小剂量硬化剂（联合组），２１例接受胃镜下食管静脉曲张结扎术（ＥＶＬ组），２３例接受小剂量硬化剂注射（ＥＳ组），三组病人一般情况具有可比性（Ｐ＞００５）。联合组首先静脉内注射硬化剂，然后行结扎。结果达到治愈标准联合组治疗２５６次，ＥＶＬ组治疗３３８次，ＥＳ组治疗４４８次，三组间均有显著性差异（Ｐ＜００５）。追踪观察１２个月，再现率联合组为８％，ＥＶＬ组为３３３３％，ＥＳ组为１７３９％，联合组与ＥＶＬ组有显著差异（Ｐ＜００５），与ＥＳ组无显著差异（Ｐ＞００５。结论联合组达到治愈标准的次数比ＥＳ组和ＥＶＬ组少，再现率低于ＥＶＬ组。 Objective To observe the efficacy of endoscopic esophageal variceal ligation combined with a small dose of sclerotherapy (combination group) in the treatment of esophageal varices. Methods Sixty-nine patients with stable esophageal variceal bleeding were randomly divided into three groups. Twenty-five patients underwent endoscopic esophageal variceal ligation combined with low dose of sclerotherapy (combination group) and 21 patients underwent endoscopic esophageal varices ligation (EVL Group), and 23 patients underwent ESR (ES group). The general conditions of the three groups were comparable (P> 005). Joint group first intravenous sclerotherapy, and then ligation. The results achieved cure standard combination group 2  56 times, EVL group 3  38 times, ES group 4  48 times, between the three groups were significantly different (P <0  05). After 12 months of follow-up, the recurrence rate was 8% in the combination group, 3333% in the EVL group and 1739% in the ES group. There was significant difference between the combined group and the EVL group (P <005) (P> 0.05) .Conclusion The number of healing criteria in combination group is less than that in ES group and EVL group, and the recurrence rate is lower than that in EVL group.