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目的评价α1肾上腺素能受体阻滞剂在输尿管下段结石体外冲击波碎石(ESWL)后辅助排石中的效果。方法96例输尿管下段结石患者随机分成对照组和治疗组，对照组单纯行ESWL治疗；治疗组ESWL治疗后予以口服α1肾上腺素能受体阻滞剂坦索罗辛0.4mg，1次/d。观察结石排出情况、是否再次发生肾绞痛而需要镇痛药治疗和药物的副作用。每例患者观察时间为2w。结果对照组排石率为52.1％，治疗组排石率为81.3％，两组比较具有显著性差异(P<0.05)。两组碎石后发生肾绞痛而需要镇痛治疗的患者分别为对照组20.8％和治疗组6.3％，两组比较具有显著性差异(P<0.05)。治疗组除2例发生头晕外，无其肾周血肿等不良反应发生，而对照组无不良反应发生。结论坦索罗辛能提高输尿管下段结石ESWL后的排石率，减少再次发生肾绞痛的几率，且安全有效，可作为输尿管下段结石ESWL后的辅助排石方法。“,”Objective To evaluate the efficacy of α1-adrenergic antagonist in the medical management of distal ureteral calculi with extracorporeal shock wave lithotripsy (ESWL).Methods 96 patients with distal ureteral calculi were divided into two groups randomly.The control group just do the ESWL treatment. The treatment group received tamsulosin (0.4 mg p.o QD) after ESWL.The observation of the stone expulsion, whether the recurrence of renal colic require analgesic treatment and side effects of drugs.All patients were observed 2 weeks.Results During 2 weeks,stones were expulsed in 25 patients (52.1%)of the control group and in 39 patients (81.3%) of the treatment group.The expulsion rate between the control group and the treatment group was significantly difference (P<0.05).Occurred after the two groups gravel require analgesic treatment of renal colic patients were 20.8%in the control group and the treatment group was 6.3%, the two groups have a significant difference (P<0.05).No side effect in the control group was reported,and 2 patients complained slightly dizziness in the treatment group.Conclusion Tamsulosin (α1-adrenergic antagonist)can improve the stone-free rate of distal ureteral calculi after ESWL and reduce the relapse of renal colic.As a safe and effective agent, it can be regarded as an auxiliary clearance method after ESWL for distal ureteral calculi.