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目的:检测系统性红斑狼疮(SLE)患者血浆中骨桥蛋白(OPN)水平,并探讨OPN在SLE疾病进程中的作用。方法:采用ELISA方法检测48例SLE患者与19例健康志愿者血浆中OPN水平;按照疾病活动指数(SLEDAI)评分,将36例住院患者分为稳定组(≤9分)和活动组(>9分),另根据肾功能、尿液分析及肾活检结果将住院患者分为肾炎组和非肾炎组,比较不同组之间血浆OPN水平的差异。结果:SLE患者外周血血浆中OPN平均水平显著高于健康对照组(P<0.01);处于活动期的SLE患者血浆OPN平均水平明显高于稳定期(P<0.01);而合并肾炎的SLE患者血浆中OPN的表达水平也高于非肾炎组(P<0.01)。结论:SLE患者的血浆OPN水平显著升高,OPN可能在SLE发病和进展过程中发挥重要作用。
Objective: To detect the level of osteopontin (OPN) in patients with systemic lupus erythematosus (SLE) and to explore the role of OPN in the progression of SLE. Methods: The plasma levels of OPN in 48 SLE patients and 19 healthy volunteers were detected by ELISA. According to the disease activity index (SLEDAI) score, 36 inpatients were divided into stable group (≤9) and active group (≥9) The other patients were divided into nephritis group and non-nephritic group according to renal function, urinalysis and renal biopsy results. The differences of plasma OPN levels between different groups were compared. Results: The average level of OPN in peripheral blood of SLE patients was significantly higher than that of healthy controls (P <0.01). The mean level of OPN in active SLE patients was significantly higher than that of stable patients (P <0.01) The expression of OPN in plasma was also higher than that in non-nephritis group (P <0.01). Conclusion: The level of plasma OPN in patients with SLE is significantly elevated. OPN may play an important role in the pathogenesis and progression of SLE.