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目的 :探讨肺耐药蛋白 (lungresistanceprotein ,LRP)在原发性上皮性卵巢癌(POEC)组织中的表达及其临床意义。方法 :采用免疫组化SP法检测POEC 6 4例、经化疗后二次手术癌组织 2 3例以及良性卵巢肿瘤 2 1例石蜡标本中LRP的表达 ,并分析 6 4例POEC患者的临床病理资料。结果 :6 4例POEC组织中LRP阳性表达 5 3例 ,阳性率82 .8% ;2 3例化疗后癌组织中LRP阳性表达 2 3例 ,阳性率 10 0 % ;2 1例良性卵巢上皮性肿瘤中LRP阳性表达 7例 ,阳性率 33.3%。POEC中LRP的阳性表达率与良性肿瘤中表达率差异有高度显著性 (P <0 .0 1) ;化疗后癌组织中LRP的阳性表达率与初治POEC中的表达率差异有显著性 (P <0 .0 5 )。POEC组织中LRP的表达与患者年龄、组织学类型、细胞分级、临床分期和术后肿瘤残存灶大小无关 (P >0 .0 5 ) ;POEC患者LRP阳性表达组近期化疗疗效明显低于阴性表达组 (P <0 .0 5 ) ;但POEC患者LRP表达与患者术后生存时间无关 (P >0 .0 5 )。结论 :LRP在POEC组织中有较恒定的表达 ,化疗可增加POEC组织LRP表达 ,检测LRP可预测化疗近期疗效 ,指导临床化疗方案的选择。
Objective: To investigate the expression of lung resistance protein (LRP) in primary epithelial ovarian cancer (POEC) and its clinical significance. Methods: Immunohistochemical SP method was used to detect the expression of LRP in 64 cases of POEC, 23 cases of secondary surgical cancer tissue after chemotherapy and 21 cases of benign ovarian tumor. The clinical pathological data of 64 POEC patients were analyzed . Results: The positive expression rate of LRP in 63 cases of POEC tissues was 53 (82.8%). Twenty-three cases of LRP were positive in 23 cases after chemotherapy, the positive rate was 100%. Twenty-one cases of benign ovarian epitheliality LRP positive expression in 7 cases, the positive rate of 33.3%. The positive rate of LRP in POEC was significantly higher than that in benign tumor (P <0.01). The difference between the expression of LRP in POEC and that in POEC was significant (P < P <0. 05). The expression of LRP in POEC tissues was not related to the patient’s age, histological type, cell grade, clinical stage and size of postoperative residual tumor (P> 0.05). The curative effect of LRP in POEC patients was significantly lower than that in negative expression Group (P <0.05). However, the LRP expression in patients with POEC was not related to the survival time (P> 0.05). Conclusion: LRP is expressed more consistently in POEC tissues. Chemotherapy can increase the expression of LRP in POEC tissues. The detection of LRP can predict the immediate effect of chemotherapy and guide the choice of clinical chemotherapy regimen.