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本文应用常规电生理学技术,研究电刺激大鼠内侧额叶前皮质(medial prefrontal cortex,mPFC)对初级听皮层神经元频率感受野(receptive field,RF)可塑性的调制。电刺激mPFC,137个听皮层神经元(72.8%)RF可塑性受到影响,其中抑制性调制71个神经元(37.7%),易化性调制66个神经元(35.1%),其余51个神经元(27.2%)不受影响。mPFC的抑制性调制效应表现为,RF的偏移时间延长,恢复时间缩短。相反,mPFC的易化性调制效应表现为,RF的偏移时间缩短,恢复时间延长。电刺激mPFC对RF可塑性的调制与声、电刺激之间的时间间隔有关,最佳时间间隔介于5～30 ms之间。结果提示,大鼠mPFC可以调制听皮层神经元的功能活动,可能参与听觉学习记忆过程。
In this study, we used conventional electrophysiological techniques to study the modulation of RF plasticity in primary auditory cortex neurons by electrically stimulating the medial prefrontal cortex (mPFC) in rats. Electrical stimulation of mPFC induced a decrease in RF plasticity in 137 auditory cortical neurons (72.8%), of which 71 neurons were inhibited (37.7%), 66 neurons (35.1%) were facilitatively modulated, and the remaining 51 neurons (27.2%) are not affected. The inhibitory modulation effect of mPFC shows that the RF offset time is prolonged and the recovery time is shortened. In contrast, the facilitation effect of mPFC is manifested in that RF offset time is shortened and recovery time is extended. Electrical modulation mPFC RF plasticity modulation and sound, electrical stimulation of the time interval between, the best time interval between 5 ~ 30 ms. The results suggest that rat mPFC can modulate the functional activity of auditory cortex neurons and may participate in the process of auditory learning and memory.