液氮深低温技术的出现,开创了现代冷冻外科。特别自1969年Soanes用冷冻疗法治疗前列腺癌的原发病灶,发现肺部转移病灶消退,提出冷冻治疗恶性肿瘤可产生免疫反应的现象,引起学者们广泛的关注。近十多年来国内外应用冷冻治疗恶性肿瘤,发展迅速。目前不仅体表,腔道部位的恶性肿瘤可以用冷冻治疗,体腔内脏实质性肿瘤,例如肺癌、肝癌、胰 The advent of liquid nitrogen deep cryogenic technology has created a modern cryosurgery. In particular, since 1969, Soanes used cryotherapy to treat the primary lesions of prostate cancer, and found that metastatic lesions in the lung dissipated, suggesting that cryotherapy of malignant tumors can produce an immune response, which has caused widespread concern among scholars. Over the past decade or so, the use of cryotherapy at home and abroad to treat malignant tumors has developed rapidly. At present, not only the body surface but also malignant tumors in the cavities can be treated with cryotherapy. The body cavity visceral solid tumors, such as lung cancer, liver cancer, and pancreas