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目的观察多烯磷脂酰胆碱治疗抗结核药物致药物性肝炎的临床效果。方法选取抗结核药物致药物性肝炎患者64例,随机分为研究组和对照组各32例。对照组患者采用门冬氨酸钾镁治疗,研究组患者采用多烯磷脂酰胆碱治疗。对比2组患者治疗前后肝功能和临床治疗效果。结果治疗前2组患者丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)及总胆红素(TBi L)比较无明显差异(P>0.05),治疗后2组ALT、AST及TBi L均明显低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。研究组总有效率为93.75%显著高于对照组的75.00%,差异有统计学意义(P<0.05)。结论多烯磷脂酰胆碱治疗抗结核药物致药物性肝炎疗效显著,可有效改善患者肝功能,值得临床推广应用。
Objective To observe the clinical effect of polyene phosphatidylcholine on drug-induced hepatitis induced by antituberculosis drugs. Methods Sixty-four patients with drug-induced hepatitis induced by anti-TB drugs were randomly divided into study group and control group with 32 cases in each group. Patients in the control group were treated with potassium and magnesium aspartate and patients in the study group were treated with polyene phosphatidylcholine. Comparison of two groups of patients before and after treatment of liver function and clinical treatment. Results There was no significant difference in ALT, AST and TBiL between the two groups before treatment (P> 0.05). After treatment, the ALT, TBT, , AST and TBi L were significantly lower than before treatment, and the study group was lower than the control group, the difference was statistically significant (P <0.05). The total effective rate of the study group was 93.75%, which was significantly higher than that of the control group (75.00%), the difference was statistically significant (P <0.05). Conclusion Polyene phosphatidylcholine treatment of anti-TB drug-induced drug-induced hepatitis significant effect, which can effectively improve liver function in patients, it is worthy of clinical application.