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本研究用昆明种小白鼠60只,随机分为两组,实验组经腹腔接种 Erh-lish腹水癌悬液0.2ml,对照组经腹腔注射生理盐水0.2ml,两组动物于实验开始后第5天、第8天和第12天分三批平行处理进行检查。结果表明:实验组小鼠体重逐渐减轻;腹水量进行性增多,在肿瘤生长的晚期为血性腹水;实验后第8天的带瘤小鼠红细胞中 cAMP 含量增高,实验后第12天的带瘤小鼠血浆和红细胞中 cAMP 含量则降低。
In this study, 60 Kunming mice were randomly divided into two groups. The experimental group was inoculated intraperitoneally with 0.2 ml of Erh-lish ascites carcinoma suspension, and the control group was injected intraperitoneally with 0.2 ml normal saline. The animals in the two groups started at the 5th day after the start of the experiment. Days, Days 8 and 12 are processed in parallel in three batches for inspection. The results showed that mice in the experimental group gradually lost weight; ascites increased progressively, with bloody ascites at the late stage of tumor growth; cAMP levels in red blood cells of the tumor-bearing mice increased on the 8th day after the experiment, and tumors were found on the 12th day after the experiment. The cAMP content in mouse plasma and red blood cells decreased.