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乙肝病毒感染是持续血液透析(HD)病人的主要并发症,由于尿毒症病人常有免疫应答缺陷,因此对不同疫苗,包括乙肝疫苗的应答功能下降。由于重组乙肝疫苗价格昂贵,故寻找一种成功的接种方法甚为重要。本研究目的是了解重复小剂量皮内注射乙肝疫苗是否具有扩大免疫接种效果的作用。交地35例HBs-Ag、HBs-Ab、HBc-Ag、HBc-Ab阴性HD病人分为三组。Ⅰ组14例,HBsAg5μg/2周皮内注射;Ⅱ组13例,HBsAg2.5μg/2周,共5次,然后改为每周一次皮内注射;Ⅲ组8例,HBsAg10μg/4周,共5次肌肉注射,然后改为5μg/2周皮内注射,各组乙肝疫苗均用至血清转化,即出现抗HBs。
Hepatitis B virus infection is a major complication of ongoing hemodialysis (HD) patients. The response to different vaccines, including hepatitis B, is diminished as uremic patients often have deficient immune responses. Because recombinant hepatitis B vaccines are expensive, finding a successful method of vaccination is important. The aim of this study was to understand whether repetitive low-dose intradermal injections of hepatitis B vaccine have the effect of enlarging the immunization. 35 cases of HBs-Ag, HBs-Ab, HBc-Ag, HBc-Ab negative HD patients were divided into three groups. In group Ⅰ, 14 cases were injected with HBsAg 5μg / 2 weeks intradermally; group Ⅱ 13 cases, HBsAg 2.5μg / 2 weeks for 5 times, then intradermal injection once a week; Ⅲ group 8 cases, HBsAg 10μg / 4 weeks 5 intramuscular injection, and then changed to 5μg / 2 weeks intradermal injection, hepatitis B vaccine in each group were used to the serum conversion, that is, anti-HBs.