论文部分内容阅读
流行病学资料表明,AFB_1污染与肝癌发病地理分布一致;AFB_1摄入量与肝癌发病率呈正相关。AFB_1可诱发所有实验动物致肝癌,但是否肯定引起人的肝癌尚有争议。为了阻断AFB_1的致癌作用,晚期动物实验集中在食物中寻找预防剂,其中绿茶可能是一种安全和有效的保护剂。AFB_1与HBV、饮水污染、遗传等呈协同致癌作用。关于AFB_1的致癌机理远未澄清,可能与影响正常肝细胞结构、功能和抑制机体的免疫功能有关。
Epidemiological data show that AFB_1 pollution is consistent with the geographical distribution of liver cancer; AFB_1 intake is positively correlated with the incidence of liver cancer. AFB_1 can induce all experimental animals to cause liver cancer, but it is still controversial whether or not it causes human liver cancer. In order to block the carcinogenic effects of AFB_1, late animal experiments focused on finding prophylactics in foods, of which green tea may be a safe and effective protective agent. AFB_1 has a synergistic carcinogenic effect with HBV, drinking water contamination, and genetics. The carcinogenic mechanism of AFB_1 is far from being clarified, and may be related to the effects on the structure and function of normal liver cells and the suppression of the body’s immune function.