论文部分内容阅读
采用小鼠骨髓嗜多染细胞微核试验、染色体畸变试验、精子畸形试验及CHL细胞染色体畸变试验,对本所研制的N’-[4-(胡椒醛缩胺基)苯基]-N,N-二甲基乙脒代号为AH-85012进行体内及体外的诱变性研究,并进行大鼠生殖毒性研究,证明该化合物无致突变性和致畸性。
The micronucleus test of bone marrow polychromatic cells in mice, chromosome aberration test, sperm abnormality test and chromosome aberration test of CHL cells were used to investigate the effects of N ’- [4- (piperonal) aminophenyl] -N, N - dimethyl acetamidine code-named AH-85012 in vitro and in vivo mutagenicity studies and reproductive toxicity studies in rats to prove that the compound has no mutagenicity and teratogenicity.