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目的 通过对不同病程的乙型肝炎病人血清转化生长因子α(TGF α)的检测 ,探讨TGF α的变化规律及其与肝功能损害的关系 ,并对TGF α在乙型肝炎诊断中的临床意义进行初步观察。方法 采用放射免疫分析法测定了 84例乙型肝炎患者血清TGF α含量 ,同时检测了各项肝功能指标。所获数据利用计算机SPSS软件应用方差分析及相关分析法进行统计学处理。结果 ①急性肝炎、慢性肝炎 (中度 )、慢性肝炎 (重度 )病人血清TGF α含量分别为 13 744± 4 449pg/ml、12 815± 5 2 2 5pg/ml、15 892± 5 0 94pg/ml,明显高于对照组 8 3 95± 3 10 7pg/ml(P <0 0 1) ;慢性肝炎 (轻度 )病人血清TGF α含量为 8 517± 2 719pg/ml,与对照组比较差异无统计学意义 (P >0 0 5)。②肝病病人血清TGF α的变化与肝功能指标ALT、AST、ALB呈正相关关系 ,而与AKP、γ GT无关。结论 血清TGF α的检测对乙型肝炎的预后估计具有重要临床意义 ,且TGF α与肝功能损害程度相关
Objective To investigate the changes of TGFα and the relationship with TGFβ1 in patients with different stages of hepatitis B and to explore the clinical significance of TGFα in the diagnosis of hepatitis B Make a preliminary observation. Methods Serum levels of TGF α in 84 patients with hepatitis B were determined by radioimmunoassay, and the indexes of liver function were also tested. The data obtained using computer SPSS software analysis of variance and correlation analysis for statistical analysis. Results ① The levels of serum TGFα in patients with acute hepatitis, chronic hepatitis (moderate) and chronic hepatitis (severe) were 13 744 ± 4 449 pg / ml, 12 815 ± 5 2 25 pg / ml and 15 892 ± 5 0 94 pg / ml, respectively , Which was significantly higher than that of the control group (8 3 95 ± 3 10 7 pg / ml, P 0 01). The serum level of TGF α in the patients with chronic hepatitis (mild) was 8517 ± 2719 pg / ml, which was not statistically different from the control group Significance of learning (P> 0.05). ② The change of serum TGF-α in patients with liver disease is positively correlated with ALT, AST and ALB, but not with AKP and γ-GT. Conclusion The detection of serum TGF-α has important clinical significance in estimating the prognosis of hepatitis B, and TGFα is associated with the degree of liver damage