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目的:探讨新发2型糖尿病和合并冠心病的患者血清护骨素水平及其相互关系。方法:新诊断的2型糖尿病患者以及新诊断的2型糖尿病合并冠心病患者各50例,另选年龄性别相匹配的50例健康者为对照组,采用ELISA法检测血清OPG水平,并计算其与FPG、2 hPG、HbA1C以及Hcy的相关性。结果:血清同型半胱氨酸和护骨素在2型糖尿病组(DM组)及糖尿病合并冠心病组(DMCVD组)明显高于对照组,而且DMCVD组与DM组之间存在显著差异。DM组与血清护骨素水平与FPG、2hPG、HbA1C及Hcy呈明显正相关。结论:血清护骨素在糖尿病以及糖尿病合并冠心病患者中明显升高,两者有相关性,护骨素可能提示糖尿病患者的亚临床动脉粥样硬化。
Objective: To explore the serum levels of osteoprotegerin in patients with newly diagnosed type 2 diabetes mellitus and coronary heart disease and their correlation. Methods: Fifty newly diagnosed patients with type 2 diabetes mellitus and newly diagnosed type 2 diabetes mellitus with coronary heart disease were enrolled. 50 healthy people of the same age and sex matched each other as the control group. Serum OPG levels were measured by ELISA. Correlation with FPG, 2 hPG, HbA1C and Hcy. Results: Serum homocysteine and osteoprotegerin in DM group and DMVD group were significantly higher than those in control group, but there was significant difference between DMCVD group and DM group. The levels of serum osteoprotegerin in DM group and serum were positively correlated with FPG, 2hPG, HbA1C and Hcy. Conclusion: The serum osteoprotegerin is significantly elevated in patients with diabetes mellitus and diabetes mellitus complicated with coronary heart disease, and the correlation between them is that osteoprotegerin may indicate subclinical atherosclerosis in diabetic patients.