患者女,36岁,因患肺结核于1984年12月19日入结核病院治疗。三年前曾服过利福平每天450mg,连服半年。此次于1985年3月19日晨空腹内服利福平225mg,服后10分钟,自觉头晕、呕吐、呼吸困难、窘迫感,继而面色苍白,口唇发绀,血压测不到,脉搏摸不清。经过三个小时抢救,血压、呼吸、脉搏恢复正常。四天后出现黄疸,一周后尿量减少,继而无尿持续7天,全身逐渐浮肿,呼吸困难,于4月2日出现心动过缓,52次/分,心电图提示为Ⅲ度房室传导阻滞,伴完全性右束支阻滞,两次阿——斯综合征晕厥发作,经心肺复苏抢救均恢复,以急性肾衰入院。既往无肾炎及泌尿系感染史。体检:T35.5℃,P56次/分,R20次/分,Bp170/90mmHg,重病客,半卧位,面部及四肢、躯干部高度浮肿。体表淋巴结不大。巩膜黄 Female patient, 36 years old, suffering from pulmonary tuberculosis in December 19, 1984 into the tuberculosis treatment. Three years ago served rifampicin daily 450mg, and even served six months. The morning of March 19, 1985 morning fasting rifampicin 225mg, 10 minutes after service, consciously dizzy, vomiting, dyspnea, feeling of distress, and then pale, lips cyanosis, blood pressure can not be measured, the pulse is not clear. After three hours of rescue, blood pressure, breathing, pulse returned to normal. Jaundice appeared four days later. After one week, the urine output decreased, followed by anuria for 7 days. The whole body gradually developed edema and dyspnea. Bradycardia occurred on April 2, 52 beats / min. The electrocardiogram showed a third-degree atrioventricular block , With complete right bundle branch block, two A-Syndrome syncope episodes, resuscitation after resuscitation by cardiopulmonary resuscitation, acute renal failure hospitalized. No past history of nephritis and urinary tract infection. Physical examination: T35.5 ℃, P56 beats / min, R20 beats / min, Bp170 / 90mmHg, serious patient, semi-recumbent position, facial and limbs, torso height edema. Small surface lymph nodes. Sclera yellow