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目的对晚期胃癌患者行手术及术中皮下埋藏腹腔化疗泵联合治疗,并对其疗效进行评价,以期对治疗提供帮助。方法对江苏省金坛市人民医院2004年4月至2007年4月收治的晚期胃癌患者中72例行手术及术中皮下埋藏腹腔化疗泵,术后采用MFP方案联合化疗。MMC8mg/m2,静脉注射,每4周1次;5-FU2.0g和DDP80mg腹腔灌注,每2周1次;平均4周为1个疗程,总疗程6～12个。结果Ⅲ期患者总有效率为77.8%;3年生存率50.0%;5年生存率25.0%。结论彻底手术加腹腔泵灌注化疗及静脉化疗是治疗晚期胃癌的有效途径,可提高患者的生活质量和生存率。
Objective To treat the patients with advanced gastric cancer undergoing surgery and intraperitoneal subcutaneous burying intraperitoneal chemotherapy combined with pump, and evaluate its efficacy, in order to provide help for the treatment. Methods Totally 72 patients undergoing surgery and subcutaneous burying intraperitoneal chemotherapy in 72 patients with advanced gastric cancer admitted from April 2004 to April 2007 in Jintan People ’s Hospital of Jiangsu Province were treated with MFP protocol combined with chemotherapy. MMC8mg / m2, intravenous injection once every 4 weeks; 5-FU2.0g and DDP80mg intraperitoneal perfusion, once every 2 weeks; an average of 4 weeks for a course of treatment, the total course of 6 to 12 months. Results The total effective rate of stage Ⅲ patients was 77.8%; 3-year survival rate was 50.0%; 5-year survival rate was 25.0%. Conclusions Thorough surgery combined with intraperitoneal perfusion chemotherapy and intravenous chemotherapy is an effective way to treat advanced gastric cancer, which can improve patients’ quality of life and survival rate.