CP-45,899是一种β-内酰胺酶抑制剂,具有有限的抗菌活性,对产生青霉素酶的细菌,本品能增强某些β-内酰胺药物的活性。在体外,氨苄青霉素和CP-45,899合并对由于产生β-内酰胺酶耐氨苄青霉素的菌敏感。为此,本报试图研究两药物联用的治疗作用、安全性和毒性试验。经涂片和培养后选择似有耐氨苄青霉素病原体引起的不危及生命的病人,静注含有500毫克氨苄青霉素和500毫克CP-45,899的0.5N生理盐水,每隔6小 CP-45,899 is a beta-lactamase inhibitor with limited antibacterial activity that increases the activity of certain beta-lactam drugs on penicillinase-producing bacteria. In vitro, the combination of ampicillin and CP-45,899 is sensitive to the bacteria resistant to ampicillin producing beta-lactamases. To this end, the newspaper tried to study the therapeutic effect of two drugs, safety and toxicity tests. After smear and culture, select patients who are life-threatening due to ampicillin-resistant pathogens and are intravenously injected with 0.5 N saline containing 500 mg ampicillin and 500 mg CP-45,899 every 6 hours