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目的探讨安全有效的奥沙利铂脱敏方案。方法对2008年1月至2009年1月年我院肿瘤科接受奥沙利铂并发生过敏的6例患者,通过稀释奥沙利铂,从1∶10000的小剂量低浓度,逐步增加直至全量,对其进行脱敏化疗。结果5例患者成功脱敏,其中2例又完成了后续3周期脱敏化疗,仅1例出现下肢皮疹、瘙痒,有效率为83.3%。结论稀释低剂量脱敏方案安全有效。
Objective To explore a safe and effective oxaliplatin desensitization protocol. Methods From January 2008 to January 2009 in our hospital oncology department received oxaliplatin and allergy in 6 patients by diluting oxaliplatin, low dose from 1: 10000 low dose gradually increased until the full amount , To desensitization chemotherapy. Results Five patients were successfully desensitized, two of them completed the subsequent three cycles of desensitization chemotherapy, and only one case had lower extremity rash and itching. The effective rate was 83.3%. Conclusion Dilution of low dose desensitization scheme is safe and effective.