论文部分内容阅读
生物玻璃的研究已达二十多年,现已成为材料学、生物化学以及分子生物学的交叉学科.由于生物玻璃具有人体硬或软生命组织有机联结的特点,在骨科、牙科、中耳等方面,对人体的伤害部位可进行修护治疗以至康健,其前景可观.生物玻璃主要由Si、Na、Ca以及P的氧化物组成.被发现具有生物活性的玻璃已有一系列组成,并且对这些系列玻璃已积累了大量的模拟人体溶液实验数据.常用的模拟人体溶液有两种:其一是Tris缓冲液;其二是离子浓度与人体液体中含量相近的模拟人体溶液.理论研究发现,当生物玻璃浸在类人体溶液中时,其表面将发生五步系列反应以及在表面建立起双电层和负的Zeta电势,从而诱导含碳的羟磷灰石在生物玻璃表面的沉积和结晶,而羟磷灰石被公认在与硬或软体组织连接中起关键作用.除溶液实验外,生物玻璃在动物移植实验中实际地发现了与硬或软组织的有机联结.基于这些研究成果,已有生物玻璃产品出现在市场上.但是,生物玻璃在世界广泛的应用,给人类医疗健康带来又一突破性进展,将取决科学研究对无机材料怎样与有机体相联结的进一步了解,以及更为广泛的积累动物和人体的实验数据.
Bioglass research for more than two decades, has now become materials science, biochemistry and molecular biology interdisciplinary. Because bio-glass has the characteristics of human body hard or soft tissue organic links, in orthopedics, dentistry, middle ear, etc., the human body injury can be part of the repair treatment and even health, its prospects are considerable. Bio-glass is mainly composed of Si, Na, Ca and P oxide. There have been a series of compositions of bioactive glass that have been found and a great deal of simulated human solution experimental data have been accumulated on these series of glasses. There are two commonly used simulated human solutions: one is Tris buffer solution and the other is simulated human solution with similar ion concentration and human body fluid content. Theoretical studies have found that when bioglass is immersed in a human-like solution, a series of five-step reactions occur on the surface of the bioglass and an electric double layer and a negative Zeta potential are established on the surface to induce the hydroxyapatite carbonaceous surface Deposition and crystallization, whereas hydroxyapatite is recognized as playing a key role in the attachment to hard or soft tissues. In addition to solution experiments, bioglass has practically found organic bonds with hard or soft tissues in animal transplantation experiments. Based on these findings, bioglass products have appeared on the market. However, the wide application of bioglass in the world has brought another breakthrough in the medical and health care of human beings. It will depend on the scientific understanding of how inorganic materials can be linked to organisms and the more extensive experimental data for animal and human accumulation .