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目的:探讨对反复着床失败的患者行子宫内膜轻创术后再行冻融胚胎移植(TET)的效果。方法:对既往有移植胚胎2次及以上着床失败经历的患者,排除各种影响因素后符合条件157例分为实验组和对照组;实验组67例行子宫内膜轻创术后再行冻融胚胎移植,对照组90例未做特殊处理常规行冻融胚胎移植。结果:实验组着床率、临床妊娠率分别为28.87%、47.76%,对照组分别为21.05%和35.56%,差异均有统计学意义(P<0.05)。实验组本次较自身前次移植周期的黄体酮转化日A型内膜形态有明显改善,分别为80.60%和61.19%,差异有统计学意义(P<0.05)。结论:子宫内膜轻创术对提高反复着床失败者冻融胚胎移植着床率是有价值的。
Objective: To investigate the effect of retrograde frozen-thawed embryo transfer (TET) after endometrial minimally invasive surgery in patients with repeated implantation failure. Methods: 157 patients with past history of implantation failure of transplanted embryos were divided into experimental group and control group after exclusion of various influencing factors. In the experimental group, 67 patients underwent endometrial minimally invasive surgery Frozen-thawed embryo transfer, 90 cases of control group without special treatment routine frozen-thawed embryo transfer. Results: The implantation rate and clinical pregnancy rate in the experimental group were 28.87% and 47.76%, respectively, and those in the control group were 21.05% and 35.56%, respectively. The differences were statistically significant (P <0.05). In the experimental group, the morphology of type A endometrium of progesterone conversion day was significantly improved compared with that of the previous transplantation period (80.60% and 61.19%, respectively), the difference was statistically significant (P <0.05). CONCLUSIONS: Endometrial minimally invasive surgery is valuable in improving the implantation rate of frozen-thawed embryos with failure of repeated implantation.