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本实验对８条犬进行小肠肌电测定，并在记录期间分别静注胆碱能神经阻断剂，阿托品和六甲季胺，以及５－羟色胺（５－ＨＴ）Ｍ受体阻断剂，灭吐灵，以观察其对红霉素所致肠道副作用的影响。结果发现阿托品和六甲季胺不仅能明显地抑制空腹时正常传播性肌电综合波（ＭＭＣ）的发生和传播，降低红霉素促进小肠动力的作用，还能减轻红霉素所致饱腹动物的快波数增加，但对呕吐无明显影响。灭吐灵的实验结果显示红霉素的致吐作用是由５－ＨＴＭ受体介导的，与其促进小肠动力的作用无明显因果关系。
In this study, eight dogs were tested for small intestinal EMG. Cholinergic blockers, atropine and hexamethonium and serotonin (5-HT) M receptor blockers were administered intravenously during recording. Turin, in order to observe its erythromycin-induced intestinal side effects. The results showed that atropine and hexamethonium not only can significantly inhibit fasting normal transmission of myoelectric synthetic wave (MMC) the occurrence and spread of erythromycin to reduce intestinal motility, but also reduce erythromycin-induced abdomen Fast wave number increased, but no significant effect on vomiting. Metoclopramide experimental results show that the emetic role of erythromycin is mediated by the 5-HTM receptor, and its role in promoting intestinal motility no significant causal relationship.