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目的综述注射剂中常用添加剂引起的不良反应及临床表现,寻求降低不良反应发生率的对策。方法根据添加剂的结构性质,对注射剂中添加剂的不良反应信息进行综述,并从合理用药、配伍禁忌和制剂等方面提出合理的改进意见。结果多数注射剂中添加剂在临床使用中均发生不同程度的不良反应。结论注射剂中的添加剂是一些药物产生不良反应的根源。
Objective To summarize the adverse reactions and clinical manifestations caused by commonly used additives in injection and to find ways to reduce the incidence of adverse reactions. Methods Based on the structural properties of the additives, the adverse reaction information of the additives in the injection was reviewed and reasonable improvements were suggested in the aspects of rational drug use, incompatibility and formulation. Results Most injections of additives in clinical use have occurred in varying degrees of adverse reactions. Conclusion The additives in injection are the root cause of some adverse drug reactions.