论文部分内容阅读
研究肺腺泡区的三维流动特性、颗粒物沉积对于理解肺部的物质输运过程及治疗呼吸系统疾病具有重要的意义。本文建立了肺腺泡区的三维对称几何模型,并通过引入动肺泡壁条件反映肺部节律收缩/扩张的动力学机制,在此基础上对非稳态呼吸时肺腺泡区的气流特性以及颗粒物沉积特性进行模拟。结果表明:随着位置逐渐下移至末端,肺泡内的流线形态从循环状向放射状变化,且流线形态在呼与吸的半周期内保持不变,颗粒物的沉积率也随肺泡的位置下移而增加。此外,通过与既有二维固定壁模型对比表明,三维模型以及动肺泡壁条件对肺部颗粒物沉积具有重要影响,不可忽略。本文对三维肺腺泡流场和颗粒物沉积的特性研究,将为肺部物质输运以及相关领域的深入研究提供可靠的理论依据。
To study the three-dimensional flow characteristics of pulmonary alveolar region, the deposition of particulate matter for the understanding of pulmonary transport of substances and treatment of respiratory diseases is of great significance. In this paper, a three-dimensional symmetrical geometric model of pulmonary acinar region was established and the kinetic mechanism of pulmonary rhythm systolic / dilatation was introduced by introducing dynamic alveolar wall conditions. Based on this, the airflow characteristics of pulmonary acinar region during unsteady respiration and Particulate deposition characteristics were simulated. The results showed that as the position gradually decreased to the end, the shape of the streamline in the alveoli changed from circular to radial, and the shape of the streamline remained unchanged during the half-cycle of exhaled and inhaled. The sedimentation rate of the particles also changed with the position of the alveoli Move down to increase. In addition, the comparison with the existing two-dimensional fixed wall model shows that the three-dimensional model and the dynamic alveolar wall conditions have an important influence on the deposition of pulmonary particles, which can not be neglected. In this paper, the study on the characteristics of three-dimensional pulmonary acinar flow field and particle deposition will provide a reliable theoretical basis for the further study of pulmonary material transport and related fields.