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目的了解哈尔滨市0岁~14岁不同人群儿童肠道病毒71型(enterovirus 71,EV71)中和抗体(neutralizing antibody,NA)水平,为防控EV71引起的手足口病流行提供科学依据,为手足口病疫苗效果评价提供基础数据。方法选取哈尔滨市4家医院作为样品采集点,采集临床排除手足口病者的样本413份,应用假病毒系统检测样本EV71中和抗体滴度,样本率的比较用χ~2检验。结果 413份样本EV71中和抗体阳性率为37.05%;不同性别、时间EV71阳性率差异均无统计学意义(P>0.05);不同年龄组儿童EV71阳性率不同,差异有统计学意义(χ~2=19.63,P<0.05)。其中≤6个月组EV71中和抗体阳性率最高,为68.00%;7个月~12个月组EV71中和抗体阳性率最低,为20.83%。结论中和抗体较低的人群及时间点为手足口病防治的重点。
Objective To investigate the levels of neutralizing antibodies (NA) in Enterovirus 71 (EV71) from 0 to 14 years of age in Harbin and to provide a scientific basis for prevention and control of EV71-induced HFMD. Stomatology vaccine efficacy evaluation provide the basic data. Methods Four hospitals in Harbin were selected as sample collection points to collect 413 samples of clinically hand-foot-mouth disease patients. The virus titer of neutralizing antibody (EV71) was detected by a pseudovirulent system. The sample rate was compared with Chi-square test. Results The positive rate of neutralizing antibody of EV71 in 413 samples was 37.05%. There was no significant difference in the positive rates of EV71 between different sexes and time (P> 0.05). The positive rates of EV71 in different age groups were different (χ ~ 2 = 19.63, P <0.05). The positive rate of neutralizing antibody of EV71 was 68.00% in ≤6months. The positive rate of neutralizing antibody of EV71 was the lowest (20.83%) in7months to12months. Conclusions The population with low neutralizing antibody and the time point are the key points for prevention and treatment of HFMD.