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阿霉素(ADM)是一种广谱、高效的抗肿瘤药物。在多种肿瘤的化疗治疗中占重要地位。ADM 的明显心脏毒性限制了其进一步提高剂量,取得更高疗效。迄今还没有一个理想的可能有效对抗 ADM 心脏毒性的药物。我科通过中西医结合减少 ADM 的心脏毒性,取得一定疗效,现报告如下:1 临床资料本组40例。均系病理证实的百何杰金病。其中男性28例,女性12例,年龄68(?)19岁,平均48岁。K 氏评分70以上。其中 B 细胞淋巴瘤8例.T 细胞淋巴瘤29例,蕈样病变3例全部系住院病人,ECG 正常。2 治疗方法全组40例,随机分为治疗组及对照组2组。所有病例均予以 CHOP 方案化疗。即 CTX600mg/m~2第1天+ADM30mg/m~2第1天+VCR1.4mg/m~2第1、8天+
Adriamycin (ADM) is a broad-spectrum, highly effective anti-tumor drug. In a variety of tumor chemotherapy treatment occupies an important position. The apparent cardiotoxicity of ADM limits its further dose enhancement and achieves higher efficacy. So far there is no ideal drug that may be effective against ADM cardiotoxicity. Our department through the combination of traditional Chinese and Western medicine to reduce ADM cardiotoxicity, and achieved a certain effect, are as follows: 1 Clinical data of 40 cases in this group. Pathology are confirmed by the Baijiejiejin disease. Including 28 males and 12 females, aged 68 (?) 19 years old, average 48 years old. K’s score of 70 or more. Including B-cell lymphoma in 8. T-cell lymphoma in 29 cases, 3 cases of all mycosis fungoides in-patient, ECG normal. 2 treatment group of 40 patients were randomly divided into treatment group and control group 2 group. All cases were given CHOP chemotherapy. Ie CTX 600mg / m 2 Day 1 + ADM 30mg / m 2 Day 1 + VCR 1.4mg / m 2 Day 1,8 +