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近年来,用吸入高渗盐水进行诱导性取痰已作为非侵入性技术方法代替支气管镜来收集哮喘患者和吸烟者的气道分泌物和炎性细胞。尽管一般认为该方法相对安全,但已有报道高渗盐水在气道高反应性者可诱发支气管收缩。因此有医师建议在诱导性取痰时应监测肺功能并应用支气管扩张剂。迄今,对诱导性取痰对哮喘患者和吸烟者血氧饱和度(SaO_2)的影响尚无报道。研究目的是观察诱导性取痰对哮喘患者、吸烟者和健康人动脉血氧饱和度和肺通气功能的影响。 14例哮喘患者(男11例、女3例,年龄18-49岁),14例吸烟史者(男5例、女9例,年龄23～64岁)及9例健康人(男7例、女2例,年龄28～54岁)参加了研究 诱导性取痰由雾化吸入3％高渗盐水5分钟,并重复2～3次来进行。哮喘患者在取痰前吸入200μg舒喘灵在诱导性取痰中,持续
In recent years, induction of sputum aspiration with hypertonic saline has been used as a non-invasive technique to replace airway secretions and inflammatory cells in asthmatics and smokers in place of bronchoscopy. Although this method is generally considered to be relatively safe, it has been reported that hypertonic saline can induce bronchoconstriction in airway hyperresponsiveness. Therefore, some doctors recommend that sputum aspiration should be monitored pulmonary function and the application of bronchodilators. To date, there is no report about the effect of induced sputum on the oxygen saturation (SaO 2) of asthma patients and smokers. The purpose of this study was to investigate the effects of induced sputum extraction on arterial oxygen saturation and pulmonary ventilation in asthmatic patients, smokers and healthy individuals. 14 patients with asthma (11 males and 3 females, aged 18-49 years), 14 patients with smoking history (5 males and 9 females, aged 23-64 years) and 9 healthy people (7 males, 2 females, aged 28-54 years) participated in the study induced sputum aspiration inhalation 3% hypertonic saline 5 minutes, and repeated 2 to 3 times to carry out. Asthma patients inhaled 200μg salbutamol prior to taking sputum in induced sputum for sustained