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目的建立吕梁地区正常孕妇血浆D-二聚体参考范围。方法本次研究对象为2014年1月至2015年12月间在山西省汾阳医院门诊和住院孕妇630例,按照孕周时间将其分为5组,采用全自动血凝仪进行检测630例孕妇的血浆D-二聚体浓度,以有效确定相应的参考范围。结果孕妇血浆D-二聚体水平伴随孕周期的增加而出现明显的上升趋势。不同孕周期组的孕妇血浆D-二聚体水平比较差异有统计学意义(P<0.05)。孕妇血浆D-二聚体正常值范围随着孕周的增加而逐渐上升,孕妇在妊娠早期略高于正常值(<0.1mg/L)。统计过程中2例孕妇静脉血栓的D-二聚体高于正常值范围,3例DIC孕妇D-二聚体检测值>20.0 mg/L。结论建立吕梁地区正常孕妇血浆D-二聚体参考区间,对提高血浆D-二聚体的检测具有重要意义。
Objective To establish a reference range of plasma D-dimer in normal pregnant women in Luliang region. Methods The study was conducted in 630 outpatients and hospitalized pregnant women in Fenyang Hospital of Shanxi Province from January 2014 to December 2015. The pregnant women were divided into 5 groups according to gestational age. 630 cases Plasma D-dimer concentrations in pregnant women to effectively determine the corresponding reference range. Results The level of D-dimer in pregnant women increased obviously with the increase of gestation period. Plasma D-dimer levels of pregnant women in different gestational age groups were significantly different (P <0.05). The range of normal plasma D-dimer in pregnant women gradually increased with the increase of gestational age, pregnant women slightly higher than normal in early pregnancy (<0.1mg / L). D-dimer of venous thrombosis in 2 pregnant women in the statistical process was higher than the normal range, and the D-dimer of 3 pregnant women with DIC was> 20.0 mg / L. Conclusion Establishing the reference interval of plasma D-dimer in normal pregnant women in Luliang region is of great significance to improve the detection of plasma D-dimer.