泰必乐(tiapride, tiapridal)由我院合成药化教研室刘贻孙等研制,为一新型神经精神安定药,除可用于老年性精神运动障碍、舞蹈病、抽动秽语综合征外,尚可治疗各种疼痛,如顽固性头痛、坐骨神经痛、关节疼痛、癌性疼痛等,也可用于酒精中毒,临床用途较广。为了向临床提供安全性资料,本文将该药的毒性试验结果,报道如下: 1 急性毒性试验(LD_(50)) 健康小白鼠18-22g,雄性,随机分组。腹腔注射组选用2个剂量,口服组为3个剂量,各组间剂量之比为1:0.7,每组10只小鼠。给药后观察 Tiapride (tiapride, tiapridal) is a new type of neuropsychiatric drug developed by the Department of Pharmacology and Pharmacy, Liu Yisun. It can not only treat senile mental disorders, chorea and Tourette’s syndrome, Pain, such as intractable headache, sciatica, joint pain, cancer pain, etc., can also be used for alcoholism, a broader clinical use. In order to provide clinical safety information, the toxicity of the drug test results reported below: 1 acute toxicity test (LD_ (50)) healthy mice 18-22g, male, randomized. Two doses were selected in the intraperitoneal injection group and three doses in the oral group. The ratio of the doses in each group was 1: 0.7, with 10 mice in each group. Observed after administration