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目的:用母牛分枝杆菌疫苗联合乙肝疫苗免疫慢性乙肝患者,观察乙肝患者免疫水平的变化。方法:将慢性乙肝患者随机分成对照组和试验组,试验组按0、1、2免疫程序,在不同部位同时接种22.5μg母牛分枝杆菌疫苗和10μg酵母乙肝疫苗,对照组接种疫苗稀释液。于免疫前后分别采血,对其CD3+CD4+、CD3+CD8+和淋巴细胞进行计数。结果:试验组与对照组之间CD3+CD4+、CD3+CD8+、淋巴细胞、CD3+CD4+/CD3+CD8+之数值比较有显著性差异。结论:母牛分枝杆菌疫苗联合乙肝疫苗免疫慢性乙肝患者,能够提高其细胞免疫的应答能力。
OBJECTIVE: To immunize patients with chronic hepatitis B with mycobacterium vaccae vaccine combined with hepatitis B vaccine to observe the changes of immunity in hepatitis B patients. Methods: Chronic hepatitis B patients were randomly divided into control group and experimental group. The experimental group was vaccinated with 22.5 μg of Mycobacterium vaccae vaccine and 10 μg of yeast hepatitis B vaccine at the same time according to 0, 1 and 2 immunization protocols. The control group was vaccinated with vaccine diluent . Blood samples were taken before and after immunization, and their CD3 + CD4 +, CD3 + CD8 + and lymphocytes were counted. Results: There were significant differences in the values of CD3 + CD4 +, CD3 + CD8 +, lymphocytes, CD3 + CD4 + / CD3 + CD8 + between the experimental group and the control group. Conclusion: Mycobacterium vaccae vaccine combined with hepatitis B vaccine in patients with chronic hepatitis B can improve their cellular immune response ability.