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为探讨急性白血病患儿尿中多胺的变化及临床意义,我们用尿试纸法检测100例健康儿童;111例急性白血病患儿不同病期尿中多胺抑制率;并对22例急淋白血病患儿化疗前后进行连续检测。结果:正常对照组尿多胺抑制率为123.8±74.5％mg肌酐;白血病组其中初发和复发65例为597.2±296.2％mg肌酐,与对照组比差异非常显著,P<0.01;完全缓解22例为118.3±76.42％mg肌酐,与对照组比无显著差异,P>0.05;部分缓解24例略高于完全缓解组,但两组均低于初发和复发组。22例急淋白血病初发时均>272.96％mg肌酐,经化疗达完全缓解后下降至正常。连续检测6～41个月,其中6例复发者再度升高同初发,余16例持续完全缓解者无1例>272.96％mg肌酐。结论:尿中多胺抑制率的水平可做为急性白血病的诊断,治疗计划的修定及病情监测的指标之一。此外尿试纸法快速、简便、经济、易于推广。
In order to explore the changes of urinary polyamines in children with acute leukemia and its clinical significance, we detected 100 cases of healthy children by urine test paper method; the polyamine inhibitory rate in urine of 111 cases of acute leukemia at different stages; and 22 cases of acute leukemia Children before and after chemotherapy for continuous testing. Results: The urinary polyamine inhibition rate in normal control group was 123.8 ± 74.5% mg creatinine; in the leukemia group, the initial and recurrent 65 cases were 597.2 ± 296.2% mg creatinine in leukemia group, with significant difference from the control group (P <0.01); complete remission The cases were 118.3 ± 76.42% mg creatinine, no significant difference compared with the control group, P> 0.05; 24 cases of partial remission slightly higher than the complete remission group, but both groups were lower than the initial and recurrence group. Twenty-two cases of acute leukemia at initial onset> 272.96% mg of creatinine, after chemotherapy to complete remission decreased to normal. Continuous detection of 6 to 41 months, of which 6 patients relapsed again with the initial onset, the remaining 16 patients with complete remission without 1 case> 272.96% mg creatinine. Conclusion: The level of polyamine inhibition in urine can be used as a diagnosis of acute leukemia, treatment plan revision and disease monitoring indicators. In addition urine test paper method is fast, easy, economical, easy to promote.