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1962年以来,已有至少500篇文献报导卡巴咪嗪(Carbamazepine,Tegretol)对癫痫有良效,多数作者报告对精神运动性(颞叶性)癲痫特别有效,对控制大发作亦有一定价值。本文随访九年来225例患者应用此药的付作用。最常见的不良反应为复视,共44例;另外14例有一过性视力模糊及“眼睛沉重感”的病例中,6例也有复视。大部分患者都在每日剂量超过1,200毫克时出现视力障碍,减量后复视都消失。白细胞减少(低于4,000)者16例,一般都在开始治疗后2～3月内发生。最初3例患轻型癲痫,用此药而出现白细胞减少,由于当时经验
Since 1962, at least 500 articles have reported that Carbamazepine (Tegretol) is effective in the treatment of epilepsy. Most authors report that it is particularly effective in the treatment of psychomotor (temporal lobe) epilepsy and is also of value in the control of major episodes . In the nine years follow-up, 225 patients were treated with the drug. The most common adverse reactions were diplopia, a total of 44 cases; the other 14 cases had transient blurred vision and “heavy eyes” in cases, 6 patients also have diplopia. Most patients have visual impairment when the daily dose exceeds 1,200 mg, and diplopia disappears after reduction. 16 cases of leukopenia (less than 4,000), usually within 2 to 3 months after starting treatment. The first three cases of mild epilepsy, leukopenia with this drug, due to the experience