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应用免疫组织化学的方法观察了８例子宫内膜间质肉瘤的Ｐ１６，Ｐ５３，Ｒｂ和ＮＭ２３的表达。结果显示所有８例标本Ｒｂ均表达阳性，而Ｐ１６则表达弱阳性和阴性。８例中有两例表现浸润，破坏最明显，瘤组织穿破子宫，累及周围组织。这两例中，１例ＮＭ２３表达阴性，另１例ＮＭ２３为弱阳性和Ｐ５３弱阳性。８例中Ｐ５３仅此１例阳性。这些结果提示Ｐ１６的表达与Ｒｂ活性负相关。Ｐ５３的表达可能与肿瘤的浸润和进展有关，而ＮＭ２３则可能与此呈负相关
Immunohistochemistry was used to observe the expression of P16, P53, Rb and NM23 in 8 cases of endometrial stromal sarcoma. The results showed that all 8 samples were positive for Rb, while P16 showed weak positive and negative. Two of the eight cases showed infiltrates and the damage was most pronounced. The tumor tissue broke through the uterus and involved the surrounding tissue. Of these two cases, 1 was negative for NM23, and the other 1 was weakly positive for NM23 and weakly positive for P53. In 8 cases, P53 was only positive in 1 case. These results suggest that the expression of P16 is negatively correlated with Rb activity. The expression of P53 may be related to the infiltration and progression of tumors, while NM23 may be negatively correlated with this