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在从植物中寻找血管扩张剂的过程中,研究了泽兰(Lycopus lucidus)的化学成分。泽兰作为中药具有活血作用。先前报道,从泽兰中只分离到少数化合物。 泽兰的地上部分在常温下用甲醇提取,然后用热水提取。水提取部分用Amberlite XAD-4柱分离,甲醇洗脱部分再经过反复柱层析分离得到化合物1～4。通过直接与标准物对照和(或)与标准物的光谱数据及物理性质进行对比分析,化合物1～4分别鉴定为木犀草素7-O-葡糖醛酸苷、迷迭香酸、香茶菜素(rabdosiin)的(1S,2R)非对映异构体、schizotenuin A。
In the search for vasodilators from plants, the chemical composition of Lycopus lucidus was studied. Zeeland as a traditional Chinese medicine has a blood circulation effect. It was previously reported that only a few compounds were isolated from Zeeland. The aerial parts of Zeeland were extracted with methanol at room temperature and then extracted with hot water. The water extract fraction was separated on an Amberlite XAD-4 column, and the methanol elution fraction was further subjected to repeated column chromatography to obtain compounds 1 to 4. Compounds 1 to 4 were identified as luteolin 7-O-glucuronide, rosmarinic acid, and scented tea, respectively, by direct comparison with standard controls and/or spectral data and physical properties of the standard. The (1S,2R) diastereoisomer of rabdosiin, schizotenuin A.