目的:萘广泛应用于工业生产和使用过程,为普遍存在的环境污染物。因此萘对职业或非职业人群的健康均存在很大威胁。但至今有关慢性低浓度萘暴露对工人健康的影响,国内外尚未见文献报道。本文主要探讨萘对人体的慢性毒性效应和亚临床客观检测指标。方法:通过职业流行病学调查,全面健康监护和医学动态观察,采用世界卫生组织神经行为核心成套测试(简称 WHO/NCTB),事件相关电位P_300和神经元特异性烯醇化酶(简称NSE),血清脂质过氧化物(简称LPO),超氧化物歧化酶(简称SOD)同功酶,谷胱甘肽过氧化物酶(简称GBH—PX)等项检测手段。结果:劳动环境萘浓度监测结果平均为8.56～26.48mg/m~3。在此环境下长期萘暴露工人的白细胞、血小板减少及眼晶体混浊检出率显著高于对照组(P<0.01)。血清SOD同功酶,GBH—PX活性显著低于对照组,而LPO水平显著高于对照组(P<0.01),该实验结果与国外有关报道一致,提示长期萘暴露可致机体脂质过氧化反应增加,脂质过氧化是许多毒物致病的起点,推想长期萘暴露所致血液与眼晶体损伤可能与机体脂质过氧化反应增加有关,NCTB检查主要为消极情绪增加,记忆力下降等,事件相关电位P_300峰的潜伏期比对照组显著延长,NSE活性增高与对照组差异均呈极显著性差异(P<0.001),表明长期低浓度萘暴露可对中枢神 Objective: Naphthalene is widely used in industrial production and use process, as a common environmental pollutants. Therefore, naphthalene poses a significant threat to the health of both working and non-working people. However, up to now, the impact of chronic low concentration naphthalene exposure on workers’ health has not been reported at home and abroad. This article focuses on the naphthalene on the human chronic toxicity and subclinical objective detection indicators. Methods: Occupational epidemiological survey, comprehensive health care and medical dynamic observation were performed. WHO / NCTB, event-related potentials P_300 and neuron-specific enolase (referred to as NSE) Serum lipid peroxides (referred to as LPO), superoxide dismutase (SOD) isozyme, glutathione peroxidase (GBH-PX) and other detection methods. Results: The average concentration of naphthalene in working environment was 8.56 ~ 26.48mg / m ~ 3. In this environment, the detection rate of white blood cells, thrombocytopenia and ocular lens turbidity in workers exposed to long-term naphthalene were significantly higher than those in the control group (P <0.01). Serum SOD isozyme, GBH-PX activity was significantly lower than the control group, while LPO levels were significantly higher than the control group (P <0.01), the experimental results consistent with foreign reports, suggesting that long-term exposure to naphthalene can cause lipid peroxidation Increased reaction, lipid peroxidation is the starting point for many toxic diseases, suggesting that long-term exposure to naphthalene caused by blood and eye lens damage may be related to increased body lipid peroxidation, NCTB examination mainly for negative emotions, memory loss, events Compared with the control group, the incubation period of P_300 peak at related potentials was significantly longer, and the NSE activity increased significantly compared with the control group (P <0.001), indicating that long-term exposure to low concentrations of naphthalene could affect the central nervous system