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目的:研究高频电磁诱导铁磁热籽产热对肿瘤的定向加热。方法:将镍铜合金制作的具有较低居里温度特点的针状铁磁热籽植入小鼠肝癌组织内,从体外施加高频电磁场诱导植入瘤体内的铁磁热籽感应产热(涡流损耗),观察对瘤体加热时的温度变化和加热后的病理改变、瘤体大小及动物生存时间等。组果:200kHz、5mT 的高频电磁场诱导植入瘤体内的铁磁热籽产热可使小鼠瘤体中心温度迅速升高达50℃,并使瘤体在持续加热中维持在这一温度水平;瘤体周围与肿瘤交界处的正常组织温度升高并不明显。肿瘤组织出现大片坏死,71%小鼠瘤体消失,生存期明显延长。结论:本加热方法可达到对肿瘤治疗的定向选择和温度控制。
OBJECTIVE: To study the directional heating of tumors by high-frequency electromagnetically induced ferrothermal heat production. METHODS: Acupuncture ferromagnetic seeds with low Curie temperature characteristics were implanted into mouse hepatocellular carcinoma. The ferromagnetic heat-sensing induced heat of implanted tumors was induced by applying high-frequency electromagnetic field in vitro. Eddy Current Loss) Observe changes in temperature and heating of the tumor after heating, pathological changes, tumor size, and animal survival time. Results: The high-frequency electromagnetic field of 200 kHz and 5 mT induces ferromagnetic heat seeding in the implanted tumor. The temperature of the tumor center can be rapidly increased by 50 °C and the tumor body can be maintained at this temperature level during continuous heating. The increase in normal tissue temperature around the junction of the tumor and the tumor was not significant. Large tumor necrosis occurred in 71% of mice, and the survival time was significantly prolonged. Conclusion: This heating method can achieve targeted selection and temperature control of tumor treatment.