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D_3-羟丁酸是血酮体的主要成分,是反映糖尿病酮症及酮症酸中毒的重要指标。目前使用的尿酮体的检测是半定量,缺乏灵敏度和准确性。本文观察了50例次糖尿病酮症及酮症在中毒病人血清D_3-羟丁酸和尿酮体的监测情况,34例次糖尿病酮症酸中毒的病人,血清D_3-羟丁酸的范围在0.33～3.75mmol/L,和临床表现相符合。血清D_3-羟丁酸的检测克服了尿酮体测定灵敏度差、假阳性多的缺点,是临床糖尿病酮症酸中毒较为准确、可靠的指标。
D_3-hydroxybutyrate is the main component of blood ketone body, is an important indicator of diabetic ketosis and ketoacidosis. The current detection of urinary ketone body is semi-quantitative, the lack of sensitivity and accuracy. This article observed 50 cases of diabetic ketosis and ketosis in patients with poisoning serum D_3-hydroxybutyrate and urine ketone body monitoring, 34 cases of diabetic ketoacidosis patients, serum D_3-hydroxybutyrate in the range of 0.33 to 3.75 mmol / L, consistent with clinical manifestations. Detection of serum D_3-hydroxybutyrate overcomes the shortcomings of poor sensitivity and false positive urine ketone ketone determination, which is a more accurate and reliable indicator of clinical diabetic ketoacidosis.