目前,国内外已介绍了一些制造急性胰腺炎动物模型的方法:如大鼠胃内灌注DL-乙硫氨酸;给小鼠注射异种血清;大鼠胰实质内注射激活剂;大鼠或犬的胰主导管内注射激活剂等。比较这些方法的优劣,我们认为向动物胰主导管内逆行注入激活剂制成的急性胰腺炎模型与国人急性胰腺发生的病理过程较为符合。因此,我们采用此方法建立了大鼠急性胰腺炎的病理模 At present, some domestic and foreign methods of making animal models of acute pancreatitis have been introduced: such as gastric perfusion of DL-ethionine in rats; injection of heterologous serum into mice; intraperitoneal injection of activators of rat pancreas; Of pancreatic ductal intubation activators and so on. To compare the pros and cons of these methods, we think that the acute pancreatitis model made by retrograde injection of activator into the pancreatic duct of the animal is more in line with the pathological process of acute pancreatitis in our country. Therefore, we use this method to establish the pathological model of acute pancreatitis in rats