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目的观察复方斑蝥注射液对中晚期非小细胞肺癌化疗的增效减毒作用。方法选择60例中晚期非小细胞肺癌患者随机分为2组。2组均应用相同全身化疗方案,治疗组同时应用复方斑蝥注射液。化疗2～4个周期后进行疗效评价。结果治疗组的总有效率为59.4%,对照组的总有效率为33.3%,两组差异有统计学意义(P<0.05)。治疗组化疗后的主要毒副反应(骨髓抑制、胃肠道反应及肝肾毒性等)明显较对照组减轻。结论复方斑蝥注射液对于中晚期非小细胞肺癌化疗具有增效减毒作用。
Objective To observe the synergistic and attenuated effect of compound cantharidin injection on chemotherapy of advanced non-small cell lung cancer. Methods Sixty patients with advanced non-small cell lung cancer were randomly divided into two groups. Both groups were given the same systemic chemotherapy regimen, while the treatment group also used compound cantharidin injection. Chemotherapy 2 to 4 cycles after the efficacy evaluation. Results The total effective rate was 59.4% in the treatment group and 33.3% in the control group, with significant difference between the two groups (P <0.05). The main side effects of chemotherapy (bone marrow suppression, gastrointestinal reaction and hepatorenal toxicity, etc.) in the treatment group were significantly lower than those in the control group. Conclusions Compound cantharidin injection has a synergistic and attenuating effect on the chemotherapy of advanced non-small cell lung cancer.