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心房利纳因子(ANF)不仅在生理情况下是一种重要而强有力的利钠物质,而且是肾小球滤过率(GFR),肾血流和肾血管阻力的一种调节物。它的利尿、利钠作用部分是由于入球小动脉扩张和同时发生的出球小动脉收缩而引起的肾毛细血管压升高,继而肾小球滤过率增加来介导的。此外,它的利钠作用也受肾素—血管紧张素—醛固酮系统的抑制效应所介导和它对肾小管的直接作用。为了明确其在临床肾移植中可能的意义,作者用下述实验方案研究ANF在急性肾功能衰竭(ARF)后的作
Atrial natriuretic factor (ANF) is not only an important and potent sodium receptor under physiological conditions, but also a regulator of glomerular filtration rate (GFR), renal blood flow, and renal vascular resistance. Its diuretic, natriuretic effects are mediated, in part, by an increase in renal capillary pressure caused by the dilatation of the arterioles and the simultaneous contraction of the aorta, followed by an increase in glomerular filtration rate. In addition, its sodium-binding action is also mediated by the inhibitory effect of the renin-angiotensin-aldosterone system and its direct effect on the renal tubules. In order to clarify its possible significance in clinical renal transplantation, the authors used the following experimental protocol to study the effect of ANF after acute renal failure (ARF)