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目的：探讨心肌肌球蛋白ＡＴＰ酶活性在严重烧伤后的变化特点及其机制。方法：用热水浴法造成３０％体表面积Ⅲ度烧伤大鼠模型并测定心肌营养性血流（ＮＢＦ）、血清心肌肌球蛋白轻链Ⅰ（ＣＭＬＣ１）和心肌肌球蛋白ＡＴＰ酶活性。结果：严重烧伤２４小时内，随着ＮＢＦ的减少，ＣＭＬＣ１含量大幅度升高，心肌肌球蛋白ＡＴＰ酶活性显著下降。结论：提示心肌血液灌流不足，心肌缺血缺氧导致心肌肌球蛋白崩解是烧伤早期心肌肌球蛋白ＡＴＰ酶活性下降的重要原因之一；心肌肌球蛋白ＡＴＰ酶活性下降在烧伤早期心肌收缩性减弱的发病学中具有重要作用。
Objective: To investigate the changes of myocardial myosin ATPase activity after severe burn and its mechanism. Methods: The third-degree burn rat model with 30% body surface area was induced by hot-water bath method and the activities of cardiac nourishing blood flow (NBF), serum myocardial myosin light chain Ⅰ (CMLC1) and myocardial myosin ATPase were determined. Results: Within 24 hours after severe burns, with the decrease of NBF, the content of CMLC1 increased significantly and the activity of myocardial myosin ATPase decreased significantly. Conclusion: Insufficient myocardial blood perfusion, myocardial ischemia and hypoxia caused by myocardial myosin disintegration is one of the important reasons for the decrease of myocardial myosin ATPase activity in early stage of burn injury. Myocardial myosin ATPase activity is decreased in early burn myocardial contraction Sexually diminished epidemiology plays an important role.