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小分子多肽(含10个氨基酸或更少)易于通过鼻粘膜吸收;较大分子的多肽吸收差甚至不吸收,但应用胆盐等促进剂时,这些多肽大多能被吸收。近年来,鲑鱼降钙素(sCT,含32个氨基酸的多肽)的鼻腔喷雾剂已研制成功。报道指出,sCT不需要任何促进剂或表面活性剂的帮助即可通过鼻粘膜吸收,其血浆浓度可达100 pg/ml。健康志愿者及绝经后妇女的试验表明,sCT的鼻腔吸收与剂量有关。临床试验还表明,鼻腔给予sCT能有效地减轻绝经后骨质疏松症病人的背痛。 sCT喷雾剂中只含合成的sCT而无促进
Small molecule peptides (containing 10 amino acids or less) are easily absorbed through the nasal mucosa; peptides of larger molecules are poorly absorbed or not absorbed, but most of these peptides are absorbed when bile salts and other boosters are used. In recent years, nasal sprays of salmon calcitonin (sCT, a 32 amino acid polypeptide) have been developed. Reported that sCT can be absorbed through the nasal mucosa without the help of any accelerator or surfactant, the plasma concentration of up to 100 pg / ml. Experiments in healthy volunteers and postmenopausal women show that nasal absorption of sCT is dose-dependent. Clinical trials also show that nasal administration of sCT can effectively relieve back pain in postmenopausal osteoporosis patients. SCT sprays contain only synthetic sCT without promotion