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目的 :检测单剂量哌甲酯对注意缺陷多动障碍 (attentiondeficithyperactivitydisorder ,ADHD)儿童脑α波竞争图的影响 ,探讨其预测ADHD患儿疗效的可行性。方法 :应用脑电超慢涨落分析技术 (encephaloflutuographtechnology,ET) ,对符合DSM Ⅳ中ADHD诊断的 38例患儿在服用哌甲酯前及服药后 2h的脑电信号进行分析处理。结果 :(1)用药后ET各指标变化 :主频明显提高 (P =0 .0 0 0 ) ;O1、F7、F8、T5、T6导联 8Hz优势几率明显下降(P <0 .0 5 ) ;总熵值呈降低趋势 ,其中QC3、QP4、QO1、QO2、QT5、QT6明显降低 (P <0 .0 5 )。 (2 )用药后反应组ET特点 :用药后反应组主频明显低于用药后无反应组 (P <0 .0 5 ) ,总熵值及各脑区熵值均明显高于用药后无反应组 (P <0 .0 5 )。结论 :服用单剂量哌甲酯后ET主频、熵值的改变 ,有望成为预测ADHD儿童对哌甲酯反应性的客观依据 ;主频左移、高熵值组对于单剂量哌甲酯较为敏感
Objective: To investigate the effects of single dose methylphenidate on brain α wave competition in ADHD children and to explore its feasibility in predicting the therapeutic effect of ADHD children. Methods: Encephalofluorescencetechnology (ET) was used to analyze the EEG signals in 38 children with ADHD diagnosed with DSM Ⅳ before and after taking methylphenidate. Results: (1) The changes of ET indexes after treatment showed that the dominant frequency was significantly increased (P = 0.0000); the odds of 8Hz advantage of O1, F7, F8, T5 and T6 were significantly decreased (P <0.05) (P <0.05). The total entropy value showed a decreasing trend. QC3, QP4, QO1, QO2, QT5 and QT6 were significantly decreased (P <0.05). (2) After treatment, the reaction group ET characteristics: After treatment, the reaction group frequency was significantly lower than the non-response group (P <0.05), the total entropy and entropy of each brain area were significantly higher than the non-response after treatment Group (P <0.05). CONCLUSION: The change of the dominant frequency and entropy of ET after taking a single dose of methylphenidate is expected to be an objective basis for predicting the responsiveness of methylphenidate to children with ADHD. The shift of frequency to left and high entropy values are more sensitive to single dose of methylphenidate