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多胺(精脒,精胺)在蛋白合成活跃或生长旺盛组织中含量高,已知在核酸或蛋白质合成前先有多胺合成亢进。1971年Russell等报告癌患者尿中多胺量增加,癌经标准外科切除或抗癌剂治疗有效者多胺量可降低,与病情改变一致。作者曾报导测定白血病患者尿中多胺对诊断、疗效判定、再发与恶化的予告有临床意义,但对实体癌诊断评价目前尚不一致。本文报导各种癌患者125例(肺41;胃21;直、结肠7;肝、胆道10;肾、膀胱22;恶性淋巴瘤8;其他癌16例)、
Polyamines (spermidine, spermine) are found in high levels of active or vigorous protein synthesis. It is known that polyamine synthesis precedes the synthesis of nucleic acids or proteins. In 1971, Russell et al reported that the amount of polyamines in urine of cancer patients increased, and the amount of polyamines in cancers treated with standard surgical resection or anticancer agents could be reduced, which was consistent with the change in condition. The authors reported that the determination of polyamines in urine of patients with leukemia has clinical significance for diagnosis, efficacy judgment, recurrence and worsening, but the diagnosis of solid cancer is still not consistent. This article reports 125 cases of various cancers (lung 41; stomach 21; straight and colon 7; liver, biliary tract 10; kidney, bladder 22; malignant lymphoma 8; other cancers 16)