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目的：为了探讨肾移植后病人脂类代谢紊乱和并发心血管疾病的因素。方法：分析了４９ 例肾移植（ Ｒ Ｔ）病人血清中的脂类各组分水平，并与慢性肾功能衰竭（ Ｃ Ｒ Ｆ） 透析病人、正常健康人群作比较。结果： Ｒ Ｔ 病人血清总胆固醇（ Ｔ Ｃ） 、甘油三酯（ Ｔ Ｇ） 、低密度脂蛋白胆固醇（ Ｌ Ｄ Ｌ－ Ｃ） 、载脂蛋白 Ｂ（ａｐｏ Ｂ） 均明显高于 Ｃ Ｒ Ｆ 和健康组，而高密度脂蛋白胆固醇（ Ｈ Ｄ Ｌ－ Ｃ） 、载脂蛋白 Ａ Ｉ（ａｐｏ Ａ Ｉ） 则无显著性差异。同时通过年龄分组统计发现， Ｒ Ｔ 病人＞３０ 岁组的 Ｔ Ｃ、 Ｌ Ｄ Ｌ－ Ｃ、ａｐｏ Ｂ 三项指标已明显改变。结论：提示肾移植治疗会提前和加速脂类代谢的紊乱， Ｃｓ Ａ 等可能是导致上述后果的主要原因。
OBJECTIVE: To investigate the factors that affect the lipid metabolism and cardiovascular disease in patients after kidney transplantation. Methods: The levels of serum lipids in 49 renal transplant recipients (R T) patients were analyzed and compared with those of chronic renal failure (C R F) dialysis patients and normal healthy subjects. Results: The levels of total cholesterol (T C), triglyceride (T G), low density lipoprotein cholesterol (LDL-C) and apolipoprotein B in R T patients were significantly higher than those in C R F and Healthy group, while there was no significant difference between high-density lipoprotein cholesterol (H D L-C) and apolipoprotein A (Apo A I). At the same time by age group statistics found that R T patients> 30 years old group T C, L D L-C, apo B three indicators have been significantly changed. Conclusions: It is suggested that renal transplantation can accelerate the disorder of lipid metabolism in advance, and CsA may be the main cause of the above-mentioned consequences.