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目的:分析探讨三联疗法与序贯疗法在长期服用拜阿司匹林者根除Hp的疗效。方法:现选取我院2014年6月-2016年6月期间到我科就诊的长期服用拜阿司匹林患者50例作为三联组,施以三联疗法;另选取同时期长期服用拜阿司匹林患者50例作为序贯组,施以序贯疗法,然后对两组患者Hp的根除情况进行比较。结果:治疗后,序贯组患者的血清中PGⅠ以及PGⅡ含量比之于三联组要明显偏低,而PGⅠ/PGⅡ比之于三联组明显偏高,组间差异明显;序贯组患者血清中的Hp-IgG抗体的含量比之于三联组患者明显偏低,相应Hp的根除率比之于三联组也明显偏高,组间差异明显,P<0.05,具有统计学意义。结论:与三联疗法相比,序贯疗法对于治疗长期服用拜阿司匹林者根除Hp的效果显著,值得在临床上推广应用。
Objective: To investigate the efficacy of triple therapy and sequential therapy in the long-term use of aspirin eradication Hp. Methods: Selected from our hospital from June 2014 to June 2016 period to our department for long-term use of aspirin in 50 patients as a triple group, triple therapy; choose the same period of long-term use of aspirin in 50 patients as a sequence Throughout the group, sequential therapy was administered, and then Hp eradication was compared between the two groups. Results: Serum levels of PGⅠ and PGⅡ were significantly lower in the sequential group than those in the triple group, while the PGⅠ / PGⅡ levels were significantly higher in the triple group than in the triple group, with significant differences between the groups Hp-IgG antibody level was significantly lower than the triple group patients, the corresponding Hp eradication rate was significantly higher than the triple group, significant difference between groups, P <0.05, with statistical significance. Conclusion: Compared with the triple therapy, sequential therapy for the treatment of long-term use of aspirin eradication Hp significant effect, it is worth in the clinical application.