多系统萎缩(MSA)是一种散发性进展性原因不明的神经变性疾病,临床特征为合并存在小脑、锥体束、锥体外系和自主神经障碍。许多患者先出现锥体外系症状后出现自主神经障碍或/及小脑体征;或以自主神经障碍起病;或先表现为小脑体征后出现自主神经或锥体外系症状。仅有锥体外系和自主神经障碍的患者经神经病理证实多数也存在小脑和脑干变性。MSA包 Multiple system atrophy (MSA) is a sporadic, progressive, unexplained neurodegenerative disease characterized by the presence of cerebellar, pyramidal tract, extrapyramidal and autonomic dysfunction. Many patients show signs of autonomic dysfunction and / or cerebellum after symptoms of extrapyramidal symptoms first; or they start with autonomic dysfunction; or appear as autonomic or extrapyramidal symptoms after signs of cerebella. Only patients with extrapyramidal and autonomic neurological deficits were confirmed by neuropathology. Most of them also had cerebellar and brainstem degeneration. MSA package