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目的研究分化抑制因子-1(Id-1)在胃癌中的表达及其与胃癌临床病理学指标间的关系,探讨其临床病理意义。方法应用免疫组化SP法检测60例胃癌组织,60例癌旁组织及30例正常胃黏膜中Id-1的表达。结果胃癌组织、癌旁组织和正常胃黏膜组织的Id-1阳性表达率分别为73.3%、21.7%、6.7%。在胃癌不同分化程度、浸润深度、TNM分期和有无淋巴结转移,Id-1表达有统计学意义(P<0.05),而与不同年龄、性别及有无远处转移无统计学意义(P>0.05)。结论 Id-1高表达与胃癌的发生发展存在着密切的关系,可作为判断胃癌浸润转移的参考指标。
Objective To study the expression of differentiation inhibitory factor-1 (Id-1) in gastric cancer and its relationship with clinicopathological parameters of gastric cancer, and to explore its clinicopathological significance. Methods Immunohistochemical SP method was used to detect the expression of Id-1 in 60 cases of gastric carcinoma, 60 cases of paracancerous tissues and 30 cases of normal gastric mucosa. Results The positive rate of Id-1 expression in gastric cancer tissues, paracancerous tissues, and normal gastric mucosa tissues were 73.3%, 21.7%, and 6.7%, respectively. The expression of Id-1 was statistically significant (P<0.05) in different degree of differentiation of gastric cancer, depth of invasion, TNM staging and lymph node metastasis (P<0.05), but it was not statistically significant with different age, gender, and distant metastasis (P> 0.05). Conclusion There is a close relationship between the high expression of Id-1 and the occurrence and development of gastric cancer. It can be used as a reference index to judge the invasion and metastasis of gastric cancer.